Biosciences is a neuroscience-focused, biomedical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders.
The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson's disease, endometriosis and uterine fibroids, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines
to ease the burden of debilitating diseases and disorders, because you deserve brave science. in collaboration with Abb Vie About the Role: Neurocrine is expanding our R&D chemistry capabilities.
In this exciting new role, you will be instrumental in the success of our growing computational chemistry team. The successful candidate will be responsible for the execution of computational-driven methodologies to help design optimized compounds with balanced properties (targets, DMPK, in-vivo). Your industry knowledge will include expertise in machine learning tools, and analytics, along with expertise with structure-based design methods to support drug discovery projects in the industry,
for our growing pipeline. Your Contributions (include, but are not limited to): Projects could range from early lead identification to the late-stage optimization of advanced projects.
In particular, you will be able to join and potentially lead the development of an in-silico modeling platform within the Chemistry Department. As an active contributing member of multi-disciplinary drug discovery projects comprised of Medicinal Chemists, Biologists, DMPK & toxicologists there will be enormous opportunities to impact projects, as well as ample collaboration opportunities to share and learn from similar ML-derived predictive modeling efforts in other Neurocrine's R&D functions.
Expertise with structure-based design methods to support drug discovery projects in the industry. Experience in machine learning approaches in their application to compound design and drug discovery is essential, which would include modern AI such as Deep Learning, Generative Modeling and Knowledge Graphs, and/or classical methods of Random Forest, KPLS, SVM, etc. Knowledge about ML environments and libraries such as Tensor Flow, Py Torch, RDKit, Scikit-learn, etc. is highly desirable as well as a deep understanding of validation metrics behind ML models. Additional suggested modern contextual topics may include meaningful connection of model predictions back to chemical structures, Polypharmacology (multiple targets with similar compounds), Protein Dynamics/ Ligand Binding, Data visualization metrics, and more.
Requirements and essential functions A collaborative & team-oriented mindset is essential Responsible for the communication and presentation of computationally derived results to the discovery project teams to facilitate effective decision-making. Familiarity with well-known commercial molecular modeling software suites is also desirable such as Schrodinger, CCG, or Open Eye.
Experience with Molecular Modeling domains is required, as applied to compound design and optimization such as Pharmacophore Analyses, Library Design, virtual HTS, Diversity/Similarity Analyses, Scaffold Hopping. A demonstrated success with an overall application of several integrated approaches (ML-derived predictions, Modeling SBD/ LBD) to progressing compound design contextual in drug discovery, is highly desirable and will serve as a strong bonus to consideration. Publications, posters, or documented examples would be helpful. Comfortable with routine programming & scripting including Python, C++, and/or R.
Experience with Pipeline Pilot or Knime would be an asset. Linux administration is desirable but not essential. Exposure to harnessing large datasets including public domain datasets of chemistry related to various targets and/or chemogenomic nature would be an asset. Other duties as assigned BS degree in chemistry or related area with 4 years + relevant experience including utilizing any or all of the following Protein-ligand, modeling, Molecular Dynamics, and Homology Modeling MS degree in chemistry and 4 years of similar experience noted above OR Ph.
D. in computational chemistry or related field with 2+ years of related industry experience. #AD1Neurocrine Biosciences is an EEO/AA/Disability/Vets employer. We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description. The annual base salary we reasonably expect to pay is $103,200.00-$149,700.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills.
In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.
Biosciences is a neuroscience-focused, biomedical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders.
The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson's disease, endometriosis and uterine fibroids, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines
to ease the burden of debilitating diseases and disorders, because you deserve brave science. in collaboration with Abb Vie About the Role: We are looking for a collaborative and highly motivated scientist to join our Research team.
The primary role will be to use cell engineering techniques to generate novel, physiologically relevant cell line/disease models, perform characterization as well as develop cell-based/potency assays to support gene therapy projects. He/she will also be involved in the production and support of more complex, disease relevant primary/i PSC derived cellular models when needed. The ideal candidate must have outstanding written and verbal communication skills,
a strong work ethic, and be able to multitask and prioritize responsibilities.
This candidate will be able to work together with his or her supervisor and the team to seamlessly provide consistent support for drug discovery and development. Your Contributions (include, but are not limited to): This scientist will be an innovative thinker with the ability to work independently, design and carry out experiments and propose creative solutions to challenging problems Provide expertise for cell model development using cell engineering/transfection techniques (Crispr/Cas9), cell culture expansion and differentiation, scale up/down and cell biology/function Provide molecular and cell biology support to execute standard cell culture processes including transfection, selection, sub-cloning, clonal expansion, and banking as well as cell model characterization Design and perform in vitro cell based and potency assays to support Gene Therapy research projects Work in the lab independently and in a collaborative environment with minimal guidance to explore, develop and validate novel models for neurological disorders Help to identify, evaluate, and, where applicable, implement novel methods or technologies that would enhance workflow efficiencies and/or improve the quality of cell model deliverables Requirements: BA/BS in Biochemistry, Biology, bioengineering or a related fields and 7+ years of Biotechnology industry experience including gene therapy-specific techniques and cell model development with emphasis in Neuroscience Ph D degree in relevant discipline and 3+ years as noted above.
Biotech/medical industry experienced preferred Strong experience in developing cell models for neurological diseases, using different immortalized cell lines, neuroblastoma and/or i PSC culture/differentiation into neuronal types and cell clone characterization methods to support gene therapy projects Prior hands-on experience in biochemistry techniques including (but not limited to) q PCR, d PCR, western blot, immunoassays, FACs analysis, protein assay development and data analysis Demonstrated hands on experience with viral (preferably AAV) and/or non-viral gene delivery for gene expression upregulation/downregulation as well as in vitro genome editing Required experience developing new biochemical and cell-based/potency assays Experience using modern automation, LIMS, data analysis and informatics systems is a plus Demonstrated ability to multi-task and be highly productive in a multidisciplinary, fast-paced and diverse environment Ability to work as part of a team; may train other team colleagues Strong communications, problem-solving, analytical thinking skills #LI-AD1Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.
We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.
The annual base salary we reasonably expect to pay is $103,200.00-$149,700.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.
Biosciences is a neuroscience-focused, biomedical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders.
The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson's disease, endometriosis and uterine fibroids, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines
to ease the burden of debilitating diseases and disorders, because you deserve brave science. in collaboration with Abb Vie About the Role: This Scientist will guide the design, development, and execution of methods for the characterization and analysis of gene therapy and other biologic-based development candidates for research, pre-clinical, and clinical use.
They will collaborate with Analytical Development leads in the lab-based analysis to determine the content and potency properties of proteins and gene therapy vectors, working cross-functionally to establish the laboratory standards for determining strength, potency and quality attributes for these late discovery and early development
candidates. Your Contributions (include, but are not limited to): Supports activities associated with the development and execution of biologically based methods relevant to protein and gene therapy products for analytical development in a Research and Development environment Performs the activities needed for in vitro analytical testing to screen engineered vector constructs including transfection and transduction read-outs Establishes assay development parameters such as specificity, linearity, precision, and repeatability of biological assays through optimization of experimental methods is preferred Demonstrates expertise in multi-well plate bioassay optimization, including ELISA-based and protein characterization methods is preferred Understands release testing methods used for viral Gene Therapy products; AAV preferred Works with a cross-function team to maintain cell lines for biologically based potency assays for Gene Therapy products, specifically AAV Contributes through authorship and review of documents for the development and establishment of analytical methods for product characterization to support research and development activities including the in-process and release testing for material manufactured for research and IND-enabling studies Represents the group during discussions with Research, Development, and collaborative stakeholders to build scientific knowledge, capabilities, and strategies by providing protein and gene therapy product characterization data to support research and product development decisions Contributes to the development of, and effective execution of, science-driven, phase appropriate, and risk-based process development strategies to support development projects in discovery and development phase programs to lead candidate nomination with responsibility to help tech transfer activities for further GMP assay development, testing Identifies and resolves technical problems through scientific understanding, options backssment, and application of innovative solutions Prepares clear and concise technical reports and participates in project team discussions Carries an internal sense of urgency to execute on strategy, vision, and direction set by line management Contributes to the decision-making processes within each project team by actively engaging in scientific and technical discussions Performs other duties as assigned Requirements: BA/BS in Biochemistry, Biology, or other relevant discipline and 5+ years of Biotechnology industry experience in biologics including gene therapy-specific techniques OR Master's/Ph D in relevant discipline and 1+ years as noted above Familiarity with product and analytical processes such as Quality by Design (Qb D) and Quality Risk Management (QRM) tools to support Clinical Manufacturing at the Dev Candidate stage in a phase-appropriate fashion, to support later phase CMC activities is a plus.
Knowledge of protein and gene therapy biology with a good understanding of testing/characterization methods required Good knowledge of cell-based methods associated with bioanalytical analytical method development (e.
g. TCID50, Potency assay, viral transduction, and ELISA methods) preferred Some experience with methods in AAV characterization (e. g. Mesoscale Diagnostics, Alpha Lisa, TCID50, Wes/JESS protein expression, Full versus Empty Characterization assays, DLS) preferred Familiar with laboratory operations, including instrument set up, maintenance, and safety Familiar level knowledge of the biologics drug development process is recommended Familiar knowledge of GLP and GMP requirements as they pertain to protein and gene therapy process development and Quality Control (QC) testing is a plus Recognizes fundamental anomalies in data points and identifies issues in experiments / processes Understands how to think outside of the technical process and consider the impact decisions will have on the broader scientific goals Strong knowledge of one scientific discipline Good knowledge of scientific principles, methods, and techniques Good knowledge and demonstrated ability working with a variety of laboratory equipment/tools Ability to work as part of a team Strong computer skills Good communications, problem-solving, analytical thinking skills Detail oriented Ability to meet deadlines Good project management skills #LI-AD1Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.
We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description. The annual base salary we reasonably expect to pay is $84,100.00-$122,050.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills.
In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.
the development of antibody therapeutics for unmet medical needs. The candidate will lead his/her own research lab and collaborate across all therapeutic areas at Genentech. This position requires effective participation in multidisciplinary teams with members from Research Biology, Drug Discovery, Developmental Sciences, and Pharma Technical Development.
Primary responsibilities will focus on two areas. Serve as molecule or project team leader to direct therapeutic antibody lead selection, optimization, and engineering for internal antibody drug discovery programs and advance of lead molecules into the clinic. Develop new and cutting-edge antibody engineering technologies (e. g. tissue
targeting, novel formats) to enable first-in-class and best-in class antibody therapeutics. The individual should leverage skills in protein engineering, structural biology, biochemistry, or computational biology to design creative and innovative solutions to address challenges in various disease areas.
Exceptionally strong leadership and communications skills are essential for the position as the individual is expected to lead an independent research group and collaborate across the organization to discover and advance next generation therapeutics. Who You Are Ph. D. in Biochemistry, Bioengineering, Biophysics, Structural Biology, or related disciplines AND post doc experience, including
at least 4 years of recent protein engineering and/or antibody engineering in academia, biotechnology and/or pharma.
Solid record of accomplishments and publications as evidence of scientific knowledge. Deep commitment to working as part of teams. Strong communication and leadership skills. Passion for problem solving via biochemistry, structural biology, protein engineering, or computational biology methods. The expected salary range for this position based on the primary location of South San Francisco, CA is $143,100 to $265,700. Annual Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.
A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits Relocation benefits are available for this job posting. Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, interactionual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.
Science Jobs refers to a category of employment that specializes in the field of science, encompassing a diverse range of professions including researchers, laboratory technicians, science educators, and many others engaged in scientific disciplines. These jobs are characterized by their focus on inquiry, exploration, and the application of scientific methods to understand the natural world. They often require a strong educational background in science, critical thinking, problem-solving skills, and sometimes, experience with specialized equipment or software. In today's world, Science Jobs are crucial for innovation, technological advancement, and addressing complex challenges in healthcare, environment, and industry.
of my knowledge. Job Description About the role: At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.
Join Takeda as a Biomarker Scientist II where you will have a good scientific background in liver fibrosis and/or metabolic dis-eases with experience in biomarker identification and development. You will be will be responsible for biomarker discovery and validation efforts for novel targets and drug candidates
and independently or collaboratively design and implement extensive biomarker research strategies to support multiple projects in collaboration with internal research teams, external partners and/or CROs.
As part of the Liver Disease Research team, you will report to the Associate Scientific Director and work with the Gastroenterology Drug Discovery Unit (GI DDU). How you will contribute: Develop and implement new biomarker concepts for the treatment of liver fibrosis and other chronic liver diseases. This includes biomarker identification, development and validation etc. Develop and oversee novel scientific biomarker projects in collaboration with internal and external partners. Establishes
project direction integrating science, key technical knowledge, and program objectives.
Perform lab bench work on target and drug candidate discovery, validation and mechanism of action studies using contemporary in vitro/ in vivo methods and tools. Participate on cross-functional teams and provide technical leadership in area of expertise. Proactively identify complex obstacles to progress in specific areas; recommend and implement solutions using a diverse set of resources; regularly add value to research projects through creative ideas. Prepare technical reports, summaries and quantitative analyses in written and/or oral form. Communicate with colleagues effectively.
Present data to other scientific staff or cross-functional project team; may present data/posters to external research or scientific community and publish research results as appropriate. Act as a biomarker lead to be involved in different stages of portfolio projects to provide input and contribute to Go or No Go decisions for various milestones. Performs as a role model supporting Takeda culture and follow policies. Minimum Requirements/Qualifications: Ph. D. degree in biology, cardio/metabolic diseases, or immunology or molecular pharmacology with relevant post-doc experience with 2+ years of experience, or MS with 8+ years of experience, or BS with 10+ years' experience.
Previous experience in NASH/chronic liver disease or fibrotic diseases or understanding of liver disease pathogenesis and pre-clinical therapeutic mechanisms of action research. Demonstrated ability to independently design and solve scientific problems using multiple, state-of-the-art technologies, experimental methods, and approaches is required. Previous experience in relevant protein and RNA-based assays as well as use of multiomic approaches for biomarker discovery, validation or development is preferred.
Previous experience and lab skills to address various types of biomarkers, modalities, and matrices, across animal models and human samples is preferred. Previous experience with translational biomarker research and working experience with clinical samples is preferred. Previous experience of using Omics platforms and collaboration with computational biologists. Good project management experience with a good understanding in various scientific disciplines in drug discovery (toxicology, DMPK, pharmacology etc. ) is a plus. Demonstrated track record by publications in scientific journals.
Good communication skills (oral, written, and presentation) and a good team player. What Takeda can offer you: Comprehensive Healthcare: Medical, Dental, and Vision Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan Health & Wellness programs including onsite flu shots and health screenings Generous time off for vacation and the option to purchase additional vacation days Community Outreach Programs and company match of charitable contributions Family Planning Support Flexible Ways of Working Tuition reimbursement More about us: At Takeda, we are transforming patient care through the development of novel specialty medicals and best in class patient support programs.
Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work. Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. Base Salary Range: $130,200.00 to $186,000.00, based on candidate professional experience level.
Employees may also be eligible for Short-term and Long-Term Incentive benefits as well. Employees are eligible to participate in Medical, Dental, Vision, Life Insurance, 401(k), Charitable Contribution Match, Holidays, Personal Days & Vacation, Tuition Reimbursement Program and Paid Volunteer Time Off. The final salary offered for this position may take into account a number of factors including, but not limited to, location, skills, education, and experience. In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.
#LI-SB1#LI-Onsite EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, interaction, interactionual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations San Diego, CA Worker Type Employee Worker Sub-Type Regular Time Type Full time
and biological scientists to perform translational oncology research around multimodal translational data sets for programs in clinical development. For this position, we are seeking a demonstrated scientific leader with a consistent and outstanding record of creativity and performance in multimodal data integration and analysis for cancer biology R&D, evidenced by peer reviewed publications in top tier journals, patent applications, and/or publicly available code repository.
As a Principal AI Scientist, you are expected to: Lead advanced machine learning and analytical method application to extract disease biology insights and support innovative clinical development programs and publications
on multimodal translational data sets that include single cell and spatial 'omics, RNAseq, ct DNA, digital pathology, and clinical data. Actively and collaboratively promote scientific and technical innovation with other members of the Department.
Direct and support publications in high quality scientific, technical or medical journals. Represent the department and translational teams externally through interactions with our key computational collaborators. Interact with key partners and investigators and effectively manage internal and external scientific collaborations. Participate and thrive in an interactive, collaborative, and team-oriented culture. Who You Are Ph D degree in a relevant
field (e. puter science, computational biology, bioinformatics, molecular biology, cancer biology, genomics).
Minimum of 3 years post-Ph D experience, with demonstrated scientific leadership in integrating, analyzing, and interpreting multimodal biological data in an academic and/or industry setting. Fluency with Python and data analysis using modern frameworks for deep learning (e. g. Pytorch, Tensor Flow-Keras). Experience with RNAseq data, systems biology tools, and pathway analysis. Excellent communication and collaboration skills. Experience with image analysis methods, particularly around spatial biology, is desirable. The expected salary range for this position based on the primary location of South San Francisco, CA is $165,600- $307,500.
Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits#g CSGenentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, interactionual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.
vivo experiments using tumor and autoimmune mouse models. As a member of our team, you will apply innovative technologies to address pertinent questions in cancer immunology and autoimmunity. Please see our relevant published work: Waite JC et al. Sci. Transl.
Med. (2020). DOI: 10.1126/scitranslmed. aba2325Skokos D et al. Sci. Transl. Med. (2020). DOI: 10.1126/scitranslmed. aaw7888As a Scientist in the Cancer Immunology team, a typical day might include the following: Planing and executing in vivo studies using mice with induced or spontaneous tumor and autoimmune disease models. Performing injections through various routes (intraperitoneal, intravenous, subcutaneous). Collecting blood
and isolating mouse tissues. Isolating immune cells from mouse and human tissues for further functional and phenotypic characterization. Performing ex-vivo immunophenotyping using multicolor flow cytometry.
Designing and executing in vitro cell-based functional assays using primary or engineered cells (molecular biology assays such as ELISA/MSD, ELISPOT, RT-PCR, flow cytometry, immune cell proliferation/cytotoxicity assay and immunofluorescence imaging). Maintaining and culturing cells as necessary. Analyzing data using Flow Jo, Microsoft Excel and Graph Pad Prism. Developing new methods or technologies, and troubleshoot experiments. Write protocols and study reports, produce, and maintain
accurate electronic records. Communicate findings to peers and management at various group and cross functional meetings.
This role might be for you if you: Enjoy working in a fast-paced environment. Learn quickly and have desire to expand your skill set with new techniques. Are detail oriented, well-organized and can multi-task effectively. Are a team player with a collaborative spirit. You have strong communication skills. To be considered for this opportunity you must have a Bachelor's or Master's degree in Immunology, Bioengineering or related fields with at least 4 years of experience working in an immunology or cancer biology laboratory. Experience conducting experiments using mouse models with training in proper handling and care of mice.
Experience in tissue culture and cell-based assays, including flow cytometry. Proficient computer skills and experience collecting and analyzing biological data. Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels! Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), interaction, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, interactionual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations.
We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process.
Please contact us to discuss any accommodations you think you may need. The salary ranges provided are shown in accordance with U. S. law and apply to U. S. based positions, where the hired candidate will be located in the U. S. If you are outside the U. S, please speak with your recruiter about salaries and benefits in your location. Salary Range (annually) $88,500.00 - $144,500.00
and executing a variety of cell-based immunological assays and in vivo experiments using tumor and autoimmune mouse models. This role will employ industry-leading technologies to address pertinent questions in cancer immunology and autoimmunity. Please see our relevant published work: Waite JC et al.
Sci. Transl. Med. (2020). DOI: 10.1126/scitranslmed. aba2325Skokos D et al. Sci. Transl. Med. (2020). DOI: 10.1126/scitranslmed. aaw7888As a Principal Scientist in the Cancer Immunology team, a typical day might include the following: Developing, optimizing, and performing various immunoassays to evaluate therapeutic candidates' impact on immune cell function and phenotype, including advanced
techniques such as multicolor flow cytometry and fluorescence microscopy. Independently planning and executing in vivo studies using tumor and autoimmune mouse models.
These will include treatments with injections through various routes (IP, IV, SC), blood and tissue collection for downstream analysis of immune responses. Analyzing data using biological and statistical software such as OMIQ, Prism, Excel, etc. Collaborating with cross-functional scientists to drive target validation and therapeutic antibody development. Delivering impactful presentations to colleagues across our business, including senior leadership. Writing protocols and study reports, maintaining accurate electronic
records. Routinely reviewing relevant literature, attending scientific meetings, and improving expertise in the field of Immunology and Immuno-Oncology.
Training and management of research associates as needed. This role might be for you if you: Get excited about developing immunotherapies that promote a tumor-specific and durable immune response to eradicate cancer for patients. Have a passion for innovation and desire to lead new scientific directions. Are a team player with a collaborative spirit. Possess excellent communication, organization, and time management skills. Independently design and execute experiments, analyze data, and interpret results. Are confident with multitasking and managing multiple projects simultaneously.
This role requires a Ph. D. in immunology, immuno-oncology, or a related field, 5+ years of relevant industry and/or academic related experience, and a strong record of innovation and publications. Proven expertise in T cell biology with experience using mouse tumor and autoimmune models, including high dimensional immunophenotyping, is required. Proficiency with fluorescence microscopy and advanced imaging techniques is a plus. Does this sound like you? Apply now to take your first steps toward living the Regeneron Way!
We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels! Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), interaction, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, interactionual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations.
We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need. The salary ranges provided are shown in accordance with U. S. law and apply to U. S. based positions, where the hired candidate will be located in the U.
S. If you are outside the U. S, please speak with your recruiter about salaries and benefits in your location. Salary Range (annually) $121,200.00 - $197,800.00
You will have the opportunity to establish manufacturing platforms and guide product development through all stages of development to ensure project advancement. This role is based in Florham Park, NJ In this role a typical day may include: Independently design studies aimed at optimizing and improving expansion and manufacturability of candidate products based on the biology and the target.
Design and execute experiments using approaches such as DOE or QBD, maintain detailed records of results, and present results to multi-disciplinary teams and leadership. Apply DOE/DQB for process characterization, establish process parameters, and contribute to CMC sections of regulatory filings.
Develop cell isolation, enrichment, separation and formulation protocols and technologies/ platforms to support product development. Develop processes that integrate innovative approaches to increase the functional capability and yield of gd T cells.
Relying on an in-depth CAR-T background, perform statistical analyses using product attribute data to assist, guide, and execute comparability studies. Develop and oversee tech transfer of protocols to CDMO. Collaborate with SME(s) at CDMOs to deliver timely and accurate technical solutions to resolve investigations and improve manufacturing performance and reliability. Present experimental outcomes, process analytics, and data trends to
larger cross functional groups and leadership. T his role may be for you if you: Enjoy the challenge of developing and improving processes for CAR-T manufacture.
Desire an opportunity to make key and highly visible contributions. Have a sound understanding in various approaches for CAR-T manufacture. Enjoy working in a matrix environment and guiding collaborations. To be considered for this role, you must have a Ph. D. + 6 years in immunology or bioengineering discipline with relevant industry experience, including cell therapy process development. We need someone with extensive hands-on experience in cell culture (primary cells and cell lines), aseptic culture, as well as genetic modification of cells using transduction and/or transfection.
Experience with gamma delta and other T cell lineages is needed. Experience in establishing cell therapy manufacturing processes and improving scalable upstream processes in the PD setting is required. Experience using wave rocker systems, benchtop bioreactors, Sepax, LOVO, and closed harvest systems will be needed. Familiarity with flow cytometry assays and other cell-based characterization assays (i. e. cytokine release and cytolytic assays) is a plus. Proven experience in the transfer of technologies/processes.
Demonstrated capability to conduct/document complex manufacturing processes, familiarity with FDA guidance's, and an understanding of GMP GDP/quality is preferred. Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels! Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), interaction, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, interactionual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations.
We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process.
Please contact us to discuss any accommodations you think you may need. The salary ranges provided are shown in accordance with U. S. law and apply to U. S. based positions, where the hired candidate will be located in the U. S. If you are outside the U. S, please speak with your recruiter about salaries and benefits in your location. Salary Range (annually) $121,200.00 - $197,800.00
of T cell biology, with a main emphasis on harnessing immunoregulatory mechanisms for reestablishing immune and tissue homeostasis under inflammatory conditions. The candidate will be expected to work independently and collaboratively on pipeline projects and will be responsible for advancing exciting and novel research stage programs into early clinical development, providing both scientific and technical expertise and generating solid proof of concept data.
No prior industry experience is required, but an open and curious scientific mind is essential. Excellent communication skills, will facilitate fruitful and open collaborations with other labs in immunology, regenerative medicine,
human genetics, biomarker discovery and early clinical development. Time and space will be provided to drive both pipeline research and also explore new biologies and pathways for new target discovery.
Using state of the art techniques and technologies, the candidate will have the capacity to develop in vitro and in vivo skills to test the involvement of novel pathways and molecules in the pathogenesis of inflammatory diseases and to identify the mechanism of action (MOA) of new targets. Strong candidates for this position will meet most of the following requirements: Ph D degree and post-doctoral experience in immunology, molecular biology, biochemistry or related field. A strong background
in T cell immunology is desirable. Demonstrated record of professional achievement in the form of high-quality publications.
Extensive hands-on experience in cellular and molecular immunology techniques including primary cell isolation from tissues, in vitro immunological assays, multi-dimensional flow cytometry and in vivo animal models. Experience with state-of-the-art precision genome editing technologies and their application for cell engineering is of particular interest. Experience with analysis of data from genomic sequencing, sc RNA-seq, TCR-seq, CITE-seq or spatial transcriptomics is a plus. Independently designing, executing and interpreting experiments.
Have excellent communication skills and willing to work in a collaborative environment and core lab. Can present research at intra- and inter-departmental meetings. Relocation benefits are available for this job postingThe expected salary range for this position based on the primary location of California is $98,200 and $182,400 of hiring range. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits#LI-JD1#researcherjob Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, interactionual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.
evaluating therapeutic candidates in these models. A strong emphasis on creativity and ingenuity to challenge existing dogmas and investigate unsolved problems in genetics medicines will be required. Your immunology expertise combined with Regeneron's technology platforms, including viral and non-viral gene therapy, CRISPR-mediated gene editing, Veloci Gene transgenic mouse models, and the extensive catalog of fully human therapeutic antibodies, will be used to make immediate contributions to the field of immunology of genetics medicines.
As a Sr. Scientist, a typical day may include the following: Design, perform, analyze, and troubleshoot in vitro and in vivo mouse experiments to investigate
and validate therapeutic targets Design, coordinate, analyze large animal model immunology-focused experiments with external vendors to inform clinical program development Design and run animal/human ELISpots, immunophenotyping, and other relevant T cell assays Collaborate with team members and provide immunological wisdom Provide occasional experimental support for existing late-stage preclinical assets in the pipeline Participate and present in departmental meetings and external conferences This role may be for you if: You enjoy working in an innovative and cross-functional team.
You have a passion for championing new immunomodulatory therapeutics. You have strong organizational, time-management,
and communication skills. You can effectively and rationally balance and prioritize multiple projects.
This role requires a Ph. D. in immunology or a related field or a B. S. /M. S. with 10 years in an immunology-focused role. A strong background in in vivo T cell biology with experience in both humans and mouse models. Experience in developing and running immune functional assays of primary human blood/tissue products is highly desired. Familiarity with the unique challenges of immune responses in gene therapies and gene editing are a plus. #LI-onsite#RGMDoes this sound like you? Apply now to take your first steps toward living the Regeneron Way!
We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels! Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), interaction, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, interactionual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations.
We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need. The salary ranges provided are shown in accordance with U. S. law and apply to U. S. based positions, where the hired candidate will be located in the U.
S. If you are outside the U. S, please speak with your recruiter about salaries and benefits in your location. Salary Range (annually) $103,600.00 - $169,000.00
The candidate will also provide molecular biology support for the group including cloning and generation of expression constructs. KEY RESPONSIBILITIES: Perform purification of recombinant proteins using chromatographic methods. QC protein reagents for different applications.
Characterize proteins via SDS-PAGE, western blot, and other biochemical and biophysical methods. Perform cloning, mutagenesis, and generate expression vectors. Ensure that experiments are planned and coordinated cross-functionally, as well as executed effectively. Handle or communicate issues in a timely manner. Provide scientific insight to overcome challenges (e. g. protein solubility, purity, heterogeneity, yield).
Continuously drive for improved process performance. Generate associated technical reports and documents. Able to work independently as well as within a team environment.
Be accountable for technical performance and help drive results of the team. QUALIFICATIONS: BS or MS in molecular biology, biochemistry, biotechnology, or other relevant biological sciences. BS with typically 3 - 7 years or MS with typically 0 - 5 years of experience. Proven experience in protein expression and purification. Familiarity with the AKTA purification system is preferred but not required. Prior experience in supporting protein structural biology and biophysical characterizations of proteins is beneficial.
Experience in cloning and related molecular biology methods.
Good problem-solving and communication skills. Good record keeping and able to efficiently manage several projects simultaneously in a dynamic environment. Position will be filled at level commensurate with extent of education, experience, and accomplishment. Abb Vie is committed to operating with integrity, driving innovation, transforming lives, serving our community, and embracing diversity and inclusion. It is Abb Vie's policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, interaction (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, interactionual orientation, marital status, status as a protected veteran, or any other legally protected group status.
of my knowledge. Job Description About the role: At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.
Join Takeda as a Biomarker Senior Scientist where you will work in the Gastroenterology Drug Discovery Unit (GI DDU) and lead efforts focused on the discovery and validation of novel biomarkers for certain drug targets in liver fibrosis and other chronic liver diseases. You will have a strong scientific background
in liver fibrosis and/or metabolic diseases with experience in biomarker identification and development. You will also be responsible for biomarker discovery and validation efforts for novel targets and drug candidates and independently design and implement extensive biomarker research strategies to support multiple projects in collaboration with internal research teams, external partners and/or CROs.
As part of the Liver Disease Research team, you will report to the Associate Scientific Director and work with the GI DDU. How you will contribute: Develop and implement new biomarker concepts for the treatment of liver fibrosis and other chronic liver diseases. This includes biomarker identification,
development and validation etc. Develop and oversee novel scientific biomarker projects in collaboration with internal and external partners.
Establishes project direction integrating science, key technical knowledge, and program objectives. Manages relevant biomarker strategy for target and drug candidate discovery, validation and mechanism of action studies using contemporary in vitro/ in vivo methods and tools. Participate on cross-functional teams and provide technical leadership in area of expertise. Proactively identify complex obstacles to progress in specific areas; recommend and implement solutions using a diverse set of resources; regularly add value to research projects through creative ideas.
Prepare technical reports, summaries and quantitative analyses in written and/or oral form. Communicate with colleagues effectively. Present data to other scientific staff or cross-functional project team; may present data/posters to external research or scientific community and publish research results as appropriate. Act as a biomarker lead to be involved in different stages of portfolio projects to provide input and contribute to Go or No Go decisions for various milestones. Performs as a role model supporting Takeda culture and follow policies.
Minimum Requirements/Qualifications: Ph. D. degree in biology, cardio/metabolic diseases, or immunology or molecular pharmacology with 3+ years relevant post-doc experience or equivalent drug discovery experience in a biotech or medical industry research setting with an additional 2+ years of experience, or MS with 9+ years of experience, or BS with 11+ years' experience. Previous experience in relevant protein and RNA-based assays as well as use of multiomic approaches for biomarker discovery, validation or development is required. Previous experience in NASH/chronic liver disease or fibrotic diseases or understanding of liver disease pathogenesis and pre-clinical therapeutic mechanisms of action research.
Demonstrated ability to independently design and solve scientific problems using multiple, state-of-the-art technologies, experimental methods, and approaches is required. Demonstrated ability to generate and implement a biomarker discovery strategy for a program in an industry setting is required. Previous experience and lab skills to address various types of biomarkers, modalities, and matrices, across animal models and human samples is preferred. Previous experience with translational biomarker research and working experience with clinical samples is preferred.
Previous experience of using Omics platforms and collaboration with computational biologists. Good understanding of current liver fibrosis biomarkers is a plus. Good project management skills with a good understanding in various scientific disciplines in drug discovery (Pharmacology, Toxicology, DMPK, etc. ) is a plus. Demonstrated track record by publications in scientific journals. Good communication skills (oral, written, and presentation) and a good team player. What Takeda can offer you: Comprehensive Healthcare: Medical, Dental, and Vision Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan Health & Wellness programs including onsite flu shots and health screenings Generous time off for vacation and the option to purchase additional vacation days Community Outreach Programs and company match of charitable contributions Family Planning Support Flexible Ways of Working Tuition reimbursement More about us: At Takeda, we are transforming patient care through the development of novel specialty medicals and best in class patient support programs.
Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work. Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. Base Salary Range: $130,200.00 to $186,000.00, based on candidate professional experience level. Employees may also be eligible for Short-term and Long-Term Incentive benefits as well.
Employees are eligible to participate in Medical, Dental, Vision, Life Insurance, 401(k), Charitable Contribution Match, Holidays, Personal Days & Vacation, Tuition Reimbursement Program and Paid Volunteer Time Off. The final salary offered for this position may take into account a number of factors including, but not limited to, location, skills, education, and experience. In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply. #LI-SB1#LI-Onsite EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, interaction, interactionual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations San Diego, CA Worker Type Employee Worker Sub-Type Regular Time Type Full time
digital pathology research for programs in clinical development. For this position, we are seeking a demonstrated scientific leader with a consistent and outstanding record of creativity and performance in digital pathology or spatial 'omics for cancer biology R&D, evidenced by peer reviewed publications in top tier journals, patent applications, and/or publicly available code repository.
As a Senior Principal Scientist, you are expected to: • Lead the application and development of digital pathology methods to extract disease biology insights and support innovative clinical development programs. • Actively and collaboratively promote scientific and technical innovation with other members
of the department, including subject matter experts in disease biology, companion diagnostics, and data science. • Direct and support publications in high quality scientific, technical, or medical journals.
• Represent the department and translational teams externally through interactions with computational collaborators. • Interact with key partners and investigators and effectively manage internal and external scientific collaborations. • Participate and thrive in an interactive, collaborative, and team-oriented culture. Who You Are: • Ph D degree in a relevant field (e. puter science, computational biology, bioinformatics, molecular biology, cancer biology). • Minimum of 7 years post-Ph
D experience, with demonstrated scientific leadership in digital pathology for oncology in academia and/or industry.
• Fluency with Python and data analysis using modern frameworks (e. g. R, Num Py). • Experience with image analysis, machine learning, and deep learning frameworks (e. g. Pytorch, Tensor Flow-Keras). • Enthusiasm for understanding and discerning the biological context of disease. • Excellent communication and collaboration skills. The expected salary range for this position based on the primary location of South San Francisco, CA is $169,800-315,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.
A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits#g CSGenentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, interactionual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.
